stable isotope-labeled peptides (Thermo Fisher)
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stable isotope-labeled peptides
Stable Isotope Labeled Peptides, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/stable+isotope-labeled+peptides/stable+isotope+labeled+heavy+peptides/pm40554317-46-2-17
Average 90 stars, based on 1 article reviews
Stable Isotope Labeled Peptides, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/stable+isotope-labeled+peptides/stable+isotope+labeled+heavy+peptides/pm40554317-46-2-17
Average 90 stars, based on 1 article reviews
stable isotope-labeled peptides - by Bioz Stars,
2026-09
90/100 stars
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Concentration Assay:Article Title: Development of a multiplex mass spectrometry method for simultaneous quantification of urinary proteins related to respiratory health Article Snippet: The stable Article Title: Quantitative transporter proteomics by liquid chromatography with tandem mass spectrometry: addressing methodologic issues of plasma membrane isolation and expression-activity relationship. Article Snippet: To predict transporter-mediated drug disposition using physiologically based pharmacokinetic models, one approach is to measure transport activity and relate it to protein expression levels in cell lines (overexpressing the transporter) and then scale these to via in vitro to in vivo extrapolation (IVIVE).. This approach makes two major assumptions.. First, that the expression of the transporter is predominantly in the plasma membrane. Article Title: Dimethandrolone, a Potential Male Contraceptive Pill, is Primarily Metabolized by the Highly Polymorphic UDP-Glucuronosyltransferase 2B17 Enzyme in Human Intestine and Liver Article Snippet: Article Title: Use of a Bile Salt Export Pump Knockdown Rat Susceptibility Model to Interrogate Mechanism of Drug-Induced Liver Toxicity. Article Snippet: Inhibition of the bile salt export pump (BSEP) may be associated with clinical drug-induced liver injury, but is poorly predicted by preclinical animal models.. Here we present the development of a novel rat model using siRNA knockdown (KD) of Bsep that displayed differentially enhanced hepatotoxicity to 8 Bsep inhibitors and not to 3 Bsep noninhibitors when administered at maximally tolerated doses for 7 days.. Bsep KD alone resulted in 3and 4.5-fold increases in liver and plasma levels, respectively, of the sum of the 3 most prevalent taurine conjugated bile acids (T3-BA), approximately 90% decrease in plasma and liver glycocholic acid, and a distinct bile acid regulating gene expression pattern, without resulting in hepatotoxicity. Article Title: Induction of complementary function reductase enzymes in colon cancer cells by dithiole-3-thione versus sodium selenite. Article Snippet: Cellular induction of reductase enzymes can alter the susceptibility of cells toward drugs and chemicals.. In this study, we compared the capacity of a single dose of sodium selenite and 3H-1,2dithiole-3-thione (D3T) to influence the drug-relevant reducing capacity of HT29 cells over time, and defined the protein-specific contribution to this activity on the basis of selected reaction monitoring mass spectrometry.. Thioredoxin reductase 1 (TrxR1) protein levels and activity were inducible up to 2.2-fold by selenium. Article Title: Determination of the Stoichiometry of the Complete Bacterial Type III Secretion Needle Complex Using a Combined Quantitative Proteomic Approach Article Snippet: Modification:Article Title: Development of a multiplex mass spectrometry method for simultaneous quantification of urinary proteins related to respiratory health Article Snippet: The stable Article Title: Quantitative transporter proteomics by liquid chromatography with tandem mass spectrometry: addressing methodologic issues of plasma membrane isolation and expression-activity relationship. Article Snippet: To predict transporter-mediated drug disposition using physiologically based pharmacokinetic models, one approach is to measure transport activity and relate it to protein expression levels in cell lines (overexpressing the transporter) and then scale these to via in vitro to in vivo extrapolation (IVIVE).. This approach makes two major assumptions.. First, that the expression of the transporter is predominantly in the plasma membrane. Article Title: Dimethandrolone, a Potential Male Contraceptive Pill, is Primarily Metabolized by the Highly Polymorphic UDP-Glucuronosyltransferase 2B17 Enzyme in Human Intestine and Liver Article Snippet: Article Title: Use of a Bile Salt Export Pump Knockdown Rat Susceptibility Model to Interrogate Mechanism of Drug-Induced Liver Toxicity. Article Snippet: Inhibition of the bile salt export pump (BSEP) may be associated with clinical drug-induced liver injury, but is poorly predicted by preclinical animal models.. Here we present the development of a novel rat model using siRNA knockdown (KD) of Bsep that displayed differentially enhanced hepatotoxicity to 8 Bsep inhibitors and not to 3 Bsep noninhibitors when administered at maximally tolerated doses for 7 days.. Bsep KD alone resulted in 3and 4.5-fold increases in liver and plasma levels, respectively, of the sum of the 3 most prevalent taurine conjugated bile acids (T3-BA), approximately 90% decrease in plasma and liver glycocholic acid, and a distinct bile acid regulating gene expression pattern, without resulting in hepatotoxicity. Article Title: Induction of complementary function reductase enzymes in colon cancer cells by dithiole-3-thione versus sodium selenite. Article Snippet: Cellular induction of reductase enzymes can alter the susceptibility of cells toward drugs and chemicals.. In this study, we compared the capacity of a single dose of sodium selenite and 3H-1,2dithiole-3-thione (D3T) to influence the drug-relevant reducing capacity of HT29 cells over time, and defined the protein-specific contribution to this activity on the basis of selected reaction monitoring mass spectrometry.. Thioredoxin reductase 1 (TrxR1) protein levels and activity were inducible up to 2.2-fold by selenium. Article Title: Determination of the Stoichiometry of the Complete Bacterial Type III Secretion Needle Complex Using a Combined Quantitative Proteomic Approach Article Snippet: Labeling:Article Title: Development of a multiplex mass spectrometry method for simultaneous quantification of urinary proteins related to respiratory health Article Snippet: The stable Article Title: Quantitative transporter proteomics by liquid chromatography with tandem mass spectrometry: addressing methodologic issues of plasma membrane isolation and expression-activity relationship. Article Snippet: To predict transporter-mediated drug disposition using physiologically based pharmacokinetic models, one approach is to measure transport activity and relate it to protein expression levels in cell lines (overexpressing the transporter) and then scale these to via in vitro to in vivo extrapolation (IVIVE).. This approach makes two major assumptions.. First, that the expression of the transporter is predominantly in the plasma membrane. Article Title: Dimethandrolone, a Potential Male Contraceptive Pill, is Primarily Metabolized by the Highly Polymorphic UDP-Glucuronosyltransferase 2B17 Enzyme in Human Intestine and Liver Article Snippet: Article Title: Use of a Bile Salt Export Pump Knockdown Rat Susceptibility Model to Interrogate Mechanism of Drug-Induced Liver Toxicity. Article Snippet: Inhibition of the bile salt export pump (BSEP) may be associated with clinical drug-induced liver injury, but is poorly predicted by preclinical animal models.. Here we present the development of a novel rat model using siRNA knockdown (KD) of Bsep that displayed differentially enhanced hepatotoxicity to 8 Bsep inhibitors and not to 3 Bsep noninhibitors when administered at maximally tolerated doses for 7 days.. Bsep KD alone resulted in 3and 4.5-fold increases in liver and plasma levels, respectively, of the sum of the 3 most prevalent taurine conjugated bile acids (T3-BA), approximately 90% decrease in plasma and liver glycocholic acid, and a distinct bile acid regulating gene expression pattern, without resulting in hepatotoxicity. Article Title: Induction of complementary function reductase enzymes in colon cancer cells by dithiole-3-thione versus sodium selenite. Article Snippet: Cellular induction of reductase enzymes can alter the susceptibility of cells toward drugs and chemicals.. In this study, we compared the capacity of a single dose of sodium selenite and 3H-1,2dithiole-3-thione (D3T) to influence the drug-relevant reducing capacity of HT29 cells over time, and defined the protein-specific contribution to this activity on the basis of selected reaction monitoring mass spectrometry.. Thioredoxin reductase 1 (TrxR1) protein levels and activity were inducible up to 2.2-fold by selenium. Article Title: Determination of the Stoichiometry of the Complete Bacterial Type III Secretion Needle Complex Using a Combined Quantitative Proteomic Approach Article Snippet: |